Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls.
نویسندگان
چکیده
BACKGROUND Association between the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and congenital heart disease (CHD) is contentious. METHODS AND RESULTS We compared genotypes between CHD cases and controls and between mothers of CHD cases and controls. We placed our results in context by conducting meta-analyses of previously published studies. Among 5814 cases with primary genotype data and 10 056 controls, there was no evidence of association between MTHFR C677T genotype and CHD risk (odds ratio [OR], 0.96 [95% confidence interval, 0.87-1.07]). A random-effects meta-analysis of all studies (involving 7697 cases and 13 125 controls) suggested the presence of association (OR, 1.25 [95% confidence interval, 1.03-1.51]; P=0.022) but with substantial heterogeneity among contributing studies (I(2)=64.4%) and evidence of publication bias. Meta-analysis of large studies only (defined by a variance of the log OR <0.05), which together contributed 83% of all cases, yielded no evidence of association (OR, 0.97 [95% confidence interval, 0.91-1.03]) without significant heterogeneity (I(2)=0). Moreover, meta-analysis of 1781 mothers of CHD cases (829 of whom were genotyped in this study) and 19 861 controls revealed no evidence of association between maternal C677T genotype and risk of CHD in offspring (OR, 1.13 [95% confidence interval, 0.87-1.47]). There was no significant association between MTHFR genotype and CHD risk in large studies from regions with different levels of dietary folate. CONCLUSIONS The MTHFR C677T polymorphism, which directly influences plasma folate levels, is not associated with CHD risk. Publication biases appear to substantially contaminate the literature with regard to this genetic association.
منابع مشابه
Association of Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T and A1298C Polymorphisms with Myocardial Infarction From North of Fars Province
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Research, Eunice Kennedy Shriver National Inst of Child Health & Human Development, National Institutes of Health, Dept of Health & Human Services, Bethesda, MD; Congenital Malformations Registry, New York State Dept of Health, Troy & Dept of Epidemiology & Biostatistics, Univ at Albany School of Public Health, Rensselaer; Wadsworth Center, New York State Dept of Health, Albany, NY; Dept of Ped...
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BACKGROUND A meta-analysis of polymorphism C677T (rs1801133) of the methylene tetrahydrofolate reductase (MTHFR) gene as a potential risk factor for congenital heart disease (CHD) in Chinese paediatric population was studied in view of the previously reported controversial results. METHODS We searched literature including PubMed, Embase, Cochrane Library, CNKI, Wanfang, and VIP databases that...
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B. Pourgheysari[1][2], A. Hasheminia[3], H. Rouhi-Boroujeni3 Received: 20/02/2014 Sent for Revision: 22/01/2014 Received Revised Manuscript: 09/10/2012 Accepted: 28/07/2012 Background and Objective: Venous thromboembolism (VTE) is one of the main causes of mortality in different human communities. Factor V Leiden, MTHFR C677T polymorphism and PLA2 polymorphism of platele...
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عنوان ژورنال:
- Circulation. Cardiovascular genetics
دوره 6 4 شماره
صفحات -
تاریخ انتشار 2013